Immune activation and induction of memory: lessons learned from controlled human malaria infection with Plasmodium falciparum.

@article{Scholzen2016ImmuneAA,
  title={Immune activation and induction of memory: lessons learned from controlled human malaria infection with Plasmodium falciparum.},
  author={Anja Scholzen and Robert W. Sauerwein},
  journal={Parasitology},
  year={2016},
  volume={143 2},
  pages={224-35}
}
Controlled human malaria infections (CHMIs) are a powerful tool to assess the efficacy of drugs and/or vaccine candidates, but also to study anti-malarial immune responses at well-defined time points after infection. In this review, we discuss the insights that CHMI trials have provided into early immune activation and regulation during acute infection, and the capacity to induce and maintain immunological memory. Importantly, these studies show that a single infection is sufficient to induce… CONTINUE READING
Related Discussions
This paper has been referenced on Twitter 4 times. VIEW TWEETS

References

Publications referenced by this paper.
Showing 1-10 of 127 references

malaria-naive subjects at a new facility for sporozoite challenge

A. C. Teirlinck, M. B. McCall, +7 authors R. W. Sauerwein
PLoS ONE 9, • 2011
View 20 Excerpts
Highly Influenced

Multiple functions of human T cells generated by experimental malaria challenge.

European journal of immunology • 2009
View 18 Excerpts
Highly Influenced

recognition of heterologous variant surface antigens after a single Plasmodium falciparum infection in previously naive adults

C. R. Engwerda, G. Minigo, F. H. Amante, J. S. McCarthy
American Journal of Tropical Medicine and Hygiene • 2012
View 1 Excerpt
Highly Influenced

Plasmodium falciparum malaria experimentally induced by mosquito challenge. Journal of Infectious Diseases

F. G. Cobelens, J. P. Verhave, Leentvaar-Kuijpers, P.A.A. andKager
1998
View 4 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…