Immune activation: the role of pro-inflammatory cytokines in inflammation, illness responses and pathological pain states

@article{Watkins1995ImmuneAT,
  title={Immune activation: the role of pro-inflammatory cytokines in inflammation, illness responses and pathological pain states},
  author={Linda R. Watkins and Steven F. Maier and Lisa Elane Goehler},
  journal={Pain},
  year={1995},
  volume={63},
  pages={289-302}
}
It has recently become accepted that the activated immune system communicates to brain via release of pro-inflammatory cytokines. This review examines the possibility that pro-inflammatory cytokines (interleukins and/or tumor necrosis factor) mediate a variety of commonly studied hyperalgesic states. We will first briefly review basic immune responses and inflammation. We will then develop the concept of illness responses and provide evidence for their existence and for the dramatic changes in… CONTINUE READING

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