Immune accessory functions of human endothelial cells are modulated by overexpression of B7-H1 (PDL1).

@article{LaGier2006ImmuneAF,
  title={Immune accessory functions of human endothelial cells are modulated by overexpression of B7-H1 (PDL1).},
  author={Adriana J. LaGier and Jordan S Pober},
  journal={Human immunology},
  year={2006},
  volume={67 8},
  pages={568-78}
}
B7-H1 (PDL1) is a B7-related protein that inhibits T-cell responses. Human endothelial cells (EC), which can support polyclonal stimulation (by anti-CD3 or Phytohemagglutinin (PHA)) or direct alloantigen stimulation of T cells, basally express B7-H1 and increase expression in response to IFN-gamma or coculture with allogeneic T cells. Previous studies have suggested that endogenous B7-H1 on EC reduces T-cell responses. We engineered overexpression of B7-H1 in EC (B7H1-EC) to evaluate whether… CONTINUE READING

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