Immune Tolerance and Rejection in Organ Transplantation.

@article{Stolp2019ImmuneTA,
  title={Immune Tolerance and Rejection in Organ Transplantation.},
  author={Jessica Stolp and Masaaki Zaitsu and Kathryn J. Wood},
  journal={Methods in molecular biology},
  year={2019},
  volume={1899},
  pages={
          159-180
        }
}
In this chapter, we describe the history of transplantation, the multiple cell types, and mechanisms that are involved in rejection and tolerance of a transplanted organ, as well as summarize the common and promising new therapeutics used in transplant patients. 
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References

SHOWING 1-10 OF 140 REFERENCES
The Significance of Non–T-Cell Pathways in Graft Rejection: Implications for Transplant Tolerance
  • X. Li
  • Biology, Medicine
    Transplantation
  • 2010
TLDR
Examining various non–T-cell types in transplant models and how such cell types interact with T cells in determining the fate of an allograft may lead to further improvement in transplant outcomes.
Natural killer T cells: a bridge to tolerance or a pathway to rejection?
TLDR
The potential role of NKT cells in transplantation will be discussed, particularly their role in rejection and the induction of a state of tolerance.
Sustained suppression by Foxp3+ regulatory T cells is vital for infectious transplantation tolerance
TLDR
A new genetic mouse model demonstrates the necessity of Foxp3+ T reg cells for infectious tolerance in mice and shows the need for further studies on this cell type in the context of infectious disease.
Passive Transfer of Transplantation Immunity
TLDR
A simple procedure for passively transferring transplantation immunity to a tumour is reported.
Antibody-mediated organ-allograft rejection
TLDR
Antibody induces rejection acutely through the fixation of complement, resulting in tissue injury and coagulation, and complement activation recruits macrophages and neutrophils, causing additional endothelial injury.
Monocytic suppressive cells mediate cardiovascular transplantation tolerance in mice.
TLDR
It is proposed that manipulating the common bone marrow monocyte progenitor could be a useful clinical therapeutic approach for inducing transplantation tolerance and mobilization of bone marrow CD11b+CD115+Gr1+ monocytes under sterile inflammatory conditions mediates the induction of indefinite allograft survival.
Regulatory lymphocytes: Regulatory T cells in transplantation tolerance
TLDR
The origin, allorecognition properties and molecular basis for the suppressive activity of CD4+CD25+ TReg cells, as well as their relationship to other populations of regulatory cells that exist after transplantation, remain a matter of debate.
Humoral autoimmunity and transplant vasculopathy: when allo is not enough.
TLDR
Results from recent clinical and experimental studies in transplantation and autoimmune diseases are collated to propose answers to questions about what triggers the response and how autoantibody causes graft damage.
Regulatory immune cells in transplantation
TLDR
The leukocyte populations that can promote immune tolerance after cell or solid-organ transplantation are discussed, including regulatory T cells, B cells and macrophages, as well as myeloid-derived suppressor cells, dendritic cells and mesenchymal stromal cells.
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