Immune Tolerance and Rejection in Organ Transplantation.

@article{Stolp2019ImmuneTA,
  title={Immune Tolerance and Rejection in Organ Transplantation.},
  author={Jessica Stolp and Masaaki Zaitsu and Kathryn J. Wood},
  journal={Methods in molecular biology},
  year={2019},
  volume={1899},
  pages={
          159-180
        }
}
In this chapter, we describe the history of transplantation, the multiple cell types, and mechanisms that are involved in rejection and tolerance of a transplanted organ, as well as summarize the common and promising new therapeutics used in transplant patients. 
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10 Citations
Background Citations
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10 Citations

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Citation Type

Clinical and Basic Research Progress on Treg-Induced Immune Tolerance in Liver Transplantation
TLDR
This review mainly summarizes the latest research advances regarding the characteristics of the hepatic immune microenvironment, operational tolerance, Treg generation in vitro, and the application of Tregs in liver transplantation to provide a deeper understanding of T Regs as the most effective treatment to induce and maintain operational tolerance after liver transplants.
Operational tolerance is early acquired and long maintained in 50% liver allograft transplantation
TLDR
It is introduced that operational tolerance, based on hypertrophy to hyperplasia switch upon liver regeneration, is early achieved and maintained well in half-size liver allograft transplantation through host bone marrow stem cells repopulation and 9-day immunosuppression.
Overview of pediatric kidney transplantation.
Safety and immunological proof-of-concept following treatment with tolerance-inducing cell products in patients with autoimmune diseases or receiving organ transplantation: A systematic review and meta-analysis of clinical trials.
Strategies for immune regulation in iPS cell-based cardiac regenerative medicine
TLDR
Recent immunomodulatory strategies in iPSC-based transplantation therapies other than MHC matching are introduced including the induction of immune tolerance through i PSC-derived antigen-presenting cells, simultaneous transplantation of syngeneic mesenchymal stem cells, and using the universal donor cells such as gene editing-based HLA modulation in i PSCs to regulate T cell compatibility.
Immunotherapy and Antivascular Targeted Therapy in Patients' Treatment with Concurrent Malignant Tumors after Organ Transplantation: Opportunity or Challenge
TLDR
Investigating the therapeutic effects and organ rejection of anti-PD-1 immunotherapy or antivascular targeting therapy on patients with combined malignancies after organ transplantation found no statistical difference between the three groups and the DCR rate for antivascular targeted therapy is approximately 60%.
HLA-G: An Important Mediator of Maternal-Fetal Immune-Tolerance
TLDR
The biological properties of HLA-G are described, the understanding of the mechanisms of fetomaternal immunologic tolerance and the difference from transplant tolerance are summarized, and how Hla-G contributes to the tolerogenic microenvironment during pregnancy is discussed.
Immunoregulation by Artemisinin and Its Derivatives: A New Role for Old Antimalarial Drugs
TLDR
Recent studies that have explored the anti-inflammatory and immunomodulatory effects of ARTs on autoimmune diseases and transplant rejection are summarized.
Simultaneous Determination of Six Immunosuppressants in Human Whole Blood by HPLC-MS/MS Using a Modified QuEChERS Method
A high-performance liquid chromatography-tandem mass spectrometry method was established for the simultaneous determination of mycophenolic acid, mycophenolate mofetil, tacrolimus, rapamycin,…
Pluripotent stem cell-based cell therapies: current applications and future prospects

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