Immune Tolerance and Rejection in Organ Transplantation.

  title={Immune Tolerance and Rejection in Organ Transplantation.},
  author={Jessica Stolp and Masaaki Zaitsu and Kathryn J. Wood},
  journal={Methods in molecular biology},
In this chapter, we describe the history of transplantation, the multiple cell types, and mechanisms that are involved in rejection and tolerance of a transplanted organ, as well as summarize the common and promising new therapeutics used in transplant patients. 
Clinical and Basic Research Progress on Treg-Induced Immune Tolerance in Liver Transplantation
This review mainly summarizes the latest research advances regarding the characteristics of the hepatic immune microenvironment, operational tolerance, Treg generation in vitro, and the application of Tregs in liver transplantation to provide a deeper understanding of T Regs as the most effective treatment to induce and maintain operational tolerance after liver transplants.
Operational tolerance is early acquired and long maintained in 50% liver allograft transplantation
It is introduced that operational tolerance, based on hypertrophy to hyperplasia switch upon liver regeneration, is early achieved and maintained well in half-size liver allograft transplantation through host bone marrow stem cells repopulation and 9-day immunosuppression.
Overview of pediatric kidney transplantation.
Strategies for immune regulation in iPS cell-based cardiac regenerative medicine
Recent immunomodulatory strategies in iPSC-based transplantation therapies other than MHC matching are introduced including the induction of immune tolerance through i PSC-derived antigen-presenting cells, simultaneous transplantation of syngeneic mesenchymal stem cells, and using the universal donor cells such as gene editing-based HLA modulation in i PSCs to regulate T cell compatibility.
Immunotherapy and Antivascular Targeted Therapy in Patients' Treatment with Concurrent Malignant Tumors after Organ Transplantation: Opportunity or Challenge
Investigating the therapeutic effects and organ rejection of anti-PD-1 immunotherapy or antivascular targeting therapy on patients with combined malignancies after organ transplantation found no statistical difference between the three groups and the DCR rate for antivascular targeted therapy is approximately 60%.
HLA-G: An Important Mediator of Maternal-Fetal Immune-Tolerance
The biological properties of HLA-G are described, the understanding of the mechanisms of fetomaternal immunologic tolerance and the difference from transplant tolerance are summarized, and how Hla-G contributes to the tolerogenic microenvironment during pregnancy is discussed.
Immunoregulation by Artemisinin and Its Derivatives: A New Role for Old Antimalarial Drugs
Recent studies that have explored the anti-inflammatory and immunomodulatory effects of ARTs on autoimmune diseases and transplant rejection are summarized.
Simultaneous Determination of Six Immunosuppressants in Human Whole Blood by HPLC-MS/MS Using a Modified QuEChERS Method
A high-performance liquid chromatography-tandem mass spectrometry method was established for the simultaneous determination of mycophenolic acid, mycophenolate mofetil, tacrolimus, rapamycin,


The Significance of Non–T-Cell Pathways in Graft Rejection: Implications for Transplant Tolerance
  • X. Li
  • Biology, Medicine
  • 2010
Examining various non–T-cell types in transplant models and how such cell types interact with T cells in determining the fate of an allograft may lead to further improvement in transplant outcomes.
Natural killer T cells: a bridge to tolerance or a pathway to rejection?
The potential role of NKT cells in transplantation will be discussed, particularly their role in rejection and the induction of a state of tolerance.
Sustained suppression by Foxp3+ regulatory T cells is vital for infectious transplantation tolerance
A new genetic mouse model demonstrates the necessity of Foxp3+ T reg cells for infectious tolerance in mice and shows the need for further studies on this cell type in the context of infectious disease.
Passive Transfer of Transplantation Immunity
A simple procedure for passively transferring transplantation immunity to a tumour is reported.
Antibody-mediated organ-allograft rejection
Antibody induces rejection acutely through the fixation of complement, resulting in tissue injury and coagulation, and complement activation recruits macrophages and neutrophils, causing additional endothelial injury.
Monocytic suppressive cells mediate cardiovascular transplantation tolerance in mice.
It is proposed that manipulating the common bone marrow monocyte progenitor could be a useful clinical therapeutic approach for inducing transplantation tolerance and mobilization of bone marrow CD11b+CD115+Gr1+ monocytes under sterile inflammatory conditions mediates the induction of indefinite allograft survival.
Regulatory lymphocytes: Regulatory T cells in transplantation tolerance
The origin, allorecognition properties and molecular basis for the suppressive activity of CD4+CD25+ TReg cells, as well as their relationship to other populations of regulatory cells that exist after transplantation, remain a matter of debate.
Humoral autoimmunity and transplant vasculopathy: when allo is not enough.
Results from recent clinical and experimental studies in transplantation and autoimmune diseases are collated to propose answers to questions about what triggers the response and how autoantibody causes graft damage.
Regulatory immune cells in transplantation
The leukocyte populations that can promote immune tolerance after cell or solid-organ transplantation are discussed, including regulatory T cells, B cells and macrophages, as well as myeloid-derived suppressor cells, dendritic cells and mesenchymal stromal cells.