Immune System Dysregulation During Spaceflight: Potential Countermeasures for Deep Space Exploration Missions

@inproceedings{Crucian2018ImmuneSD,
  title={Immune System Dysregulation During Spaceflight: Potential Countermeasures for Deep Space Exploration Missions},
  author={Brian E. Crucian and Alexander Chouk{\'e}r and Richard J. Simpson and Satish K Mehta and Gailen D. Marshall and Scott M. Smith and Sara R. Zwart and Martina Heer and S. Ponomarev and Alexandra M. Whitmire and Jean Pol Frippiat and Grace L. Douglas and Hernan A Lorenzi and Judith-Irina Buchheim and George Makedonas and Geoffrey S. Ginsburg and Christina M Ott and Duane L. Pierson and Stephanie S. Krieger and Natalie Baecker and Clarence F. Sams},
  booktitle={Front. Immunol.},
  year={2018}
}
Recent studies have established that dysregulation of the human immune system and the reactivation of latent herpesviruses persists for the duration of a 6-month orbital spaceflight. It appears certain aspects of adaptive immunity are dysregulated during flight, yet some aspects of innate immunity are heightened. Interaction between adaptive and innate immunity also seems to be altered. Some crews experience persistent hypersensitivity reactions during flight. This phenomenon may, in synergy… CONTINUE READING
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