Immune Responses in Healthy and Allergic Individuals Are Characterized by a Fine Balance between Allergen-specific T Regulatory 1 and T Helper 2 Cells

@article{Akdis2004ImmuneRI,
  title={Immune Responses in Healthy and Allergic Individuals Are Characterized by a Fine Balance between Allergen-specific T Regulatory 1 and T Helper 2 Cells},
  author={M{\"u}beccel Akdis and Johan Verhagen and Alison Taylor and Fariba Karamloo and Christian Karagiannidis and Reto Crameri and Sarah Thunberg and G{\"u}nnur Deniz and Rudolf Valenta and Helmut Fiebig and Christian Kegel and Rainer Disch and Carsten B. Schmidt-Weber and Kurt Blaser and Cezmi A. Akdis},
  journal={The Journal of Experimental Medicine},
  year={2004},
  volume={199},
  pages={1567 - 1575}
}
The mechanisms by which immune responses to nonpathogenic environmental antigens lead to either allergy or nonharmful immunity are unknown. Single allergen-specific T cells constitute a very small fraction of the whole CD4+ T cell repertoire and can be isolated from the peripheral blood of humans according to their cytokine profile. Freshly purified interferon-gamma-, interleukin (IL)-4-, and IL-10-producing allergen-specific CD4+ T cells display characteristics of T helper cell (Th)1-, Th2… CONTINUE READING
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