Immune Response Associated with Islet Xenotransplantation in Small and Large Animal Models

Abstract

This chapter will review studies that examine the immune response to porcine neona‐ tal pancreatic cell clusters (NPCC) in small and large animal models; specifically, the immune mechanisms that lead to the rejection of transplanted islet cells in mice, nonhu‐ man primates, and humans will be discussed. In addition, current research on the in vitro and in… (More)

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