Immune Regulatory Properties of Allogeneic Adipose-Derived Mesenchymal Stem Cells in the Treatment of Experimental Autoimmune Diabetes

@inproceedings{Bassi2012ImmuneRP,
  title={Immune Regulatory Properties of Allogeneic Adipose-Derived Mesenchymal Stem Cells in the Treatment of Experimental Autoimmune Diabetes},
  author={{\^E}nio Jos{\'e} Bassi and Pedro M. M. Moraes-Vieira and Carla S.R. Moreira-S{\'a} and Danilo Almeida and Leonardo Moreira Vieira and Cl{\'a}udia S{\'a} e Cunha and Meire Ioshie Hiyane and Alexandre Salgado Basso and {\'A}lvaro Pacheco-Silva and Niels O. S. C{\^a}mara},
  booktitle={Diabetes},
  year={2012}
}
Adipose-derived mesenchymal stem cells (ADMSCs) display immunosuppressive properties, suggesting a promising therapeutic application in several autoimmune diseases, but their role in type 1 diabetes (T1D) remains largely unexplored. The aim of this study was to investigate the immune regulatory properties of allogeneic ADMSC therapy in T cell-mediated autoimmune diabetes in NOD mice. ADMSC treatment reversed the hyperglycemia of early-onset diabetes in 78% of diabetic NOD mice, and this effect… CONTINUE READING