Immune Privilege and Immunogenicity Reside among Different Layers of the Mouse Cornea

@article{Hori2000ImmunePA,
  title={Immune Privilege and Immunogenicity Reside among Different Layers of the Mouse Cornea},
  author={Junko Hori and Nancy Cahill Joyce and J. Wayne Streilein},
  journal={Ocular Immunology and Inflammation},
  year={2000},
  volume={15},
  pages={225 - 239}
}
Purpose: To determine the extent to which each layer of the mouse cornea displays alloimmuno-genicity or immune privilege. Methods: Intact corneas or individual or combined layers of corneas from normal or cauterized eyes of BALB/c, C57BL/6, and CD95L-deficient B6-gld mice were grafted beneath the kidney capsule of normal BALB/c, B10.D2, BALB.B mice or of BALB/c mice presensitized to donor antigens. Graft fate was assessed clinically and histologically and acquisition of donor-specific delayed… 
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76 Citations
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76 Citations

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Corneal Endothelium Confers Immune Privilege on the Cornea as an Allograft
TLDR
Both the epithelium alone and the stroma alone display immunogenic potential, whereas the endothelium confers immune privilege through constitutive expression of CD95L.
CD95 ligand expression on corneal epithelium and endothelium influences the fates of orthotopic and heterotopic corneal allografts in mice.
TLDR
CD95L expression on epithelium of full-thickness cornea fragment grafts placed in the anterior chamber of BALB/c eyes protects these heterotopic grafts from rejection but has only a trivial role to play in determining the fate of orthotopic corneal grafts.
Role of recipient epithelium in promoting survival of orthotopic corneal allografts in mice.
TLDR
Replacement of donor epithelium with Langerhans' cell-deficient syngeneic epit Helium protects orthotopic allogeneic cornea grafts (stroma plus endothelium) from immune-mediated rejection.
Immunologic mechanisms of corneal allografts reconstituted from cultured allogeneic endothelial cells in an immune-privileged site.
TLDR
Transplantation of corneal grafts formed with allogeneic CECs could be an ideal treatment strategy to overcome postoperative rejection and indicate that immunologic ignorance rather than active immunosuppression is important for the rejection-free acceptance of chimeric CEC allografts.
Survival in high-risk eyes of epithelium-deprived orthotopic corneal allografts reconstituted in vitro with syngeneic epithelium.
TLDR
Replacement of donor epithelium with syngeneic epithelial layers protects orthotopic allogeneic corneal grafts placed in high-risk eyes from sensitizing their recipients and from immune-mediated rejection.
New thoughts on the immunology of corneal transplantation
AbstractSignificant advances derived from rodent models of penetrating keratoplasty have transformed our understanding of the pathogenesis of rejection of orthotopic corneal transplants. The high…
Dynamics of donor cell persistence and recipient cell replacement in orthotopic corneal allografts in mice.
TLDR
Whereas in mice graft-derived epithelium is largely irrelevant to corneal allograft outcome, persistence of donor-derived endothelium and keratocytes correlates perfectly with graft acceptance.
Long-Term Survival of Corneal Allografts Is Dependent on Intact CD1d-Reactive NKT Cells1
TLDR
CD1d-reactive NKT cells are required for induction of allospecific Tr cells and are essential for survival of corneal allografts and may lead to new therapies for improvement in graft survival in high-risk corneas and other transplanted tissues and grafts.
Differences in leukocyte phenotype and interferon-gamma expression in stroma and endothelium during corneal graft rejection.
GITR ligand-mediated local expansion of regulatory T cells and immune privilege of corneal allografts.
TLDR
GITRL-dependent expansion of Treg within the cornea is one mechanism underlying immune privilege in corneal allografts.
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