Immune Escape in Breast Cancer During In Situ to Invasive Carcinoma Transition.

  title={Immune Escape in Breast Cancer During In Situ to Invasive Carcinoma Transition.},
  author={Carlos Rodrigo Gil del Alcazar and Sung Jin Huh and Muhammad B. Ekram and Anne Trinh and Lin L. Liu and Francisco Beca and Xiaoyuan Zi and Minsuk Kwak and Helga Bergholtz and Ying Su and Lina Ding and Hege Giercksky Russnes and Andrea L. Richardson and Kirsten Babski and Elizabeth Min Hui Kim and Charles H. McDonnell and Jon Wagner and Ron Rowberry and Gordon J Freeman and Deborah A. Dillon and Therese Sorlie and Lisa M. Coussens and Judy E Garber and Rong Fan and Kristie Bobolis and Donald Craig Allred and Joon Jeong and So Yeon Park and Franziska Michor and Korn{\'e}lia Poly{\'a}k},
  journal={Cancer discovery},
  volume={7 10},
To investigate immune escape during breast tumor progression, we analyzed the composition of leukocytes in normal breast tissues, ductal carcinoma in situ (DCIS), and invasive ductal carcinomas (IDC). We found significant tissue and tumor subtype-specific differences in multiple cell types including T cells and neutrophils. Gene expression profiling of CD45… CONTINUE READING