Immune Dysregulation and Tumor-Associated Gene Changes in Recurrent Respiratory Papillomatosis: A Paired Microarray Analysis

@article{Devoti2008ImmuneDA,
  title={Immune Dysregulation and Tumor-Associated Gene Changes in Recurrent Respiratory Papillomatosis: A Paired Microarray Analysis},
  author={James A Devoti and David W. Rosenthal and Rong Wu and Allan L. Abramson and Bettie M. Steinberg and Vincent R Bonagura},
  journal={Molecular Medicine},
  year={2008},
  volume={14},
  pages={608-617}
}
Recurrent respiratory papillomas (RRP) are benign airway tumors, caused primarily by human papillomaviruses (HPV) types 6 and 11.The disease is characterized by multiple recurrences after surgical removal, with limited effective therapy. To identify novel targets for future therapy, we established transcriptional profiles for actively growing papillomas compared with autologous, clinically normal, laryngeal epithelia (adjacent tissue). Total ribonucleic acid (RNA) from 12 papillomas and 12… CONTINUE READING

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