Immune Cross-Opsonization Within emm Clusters Following Group A Streptococcus Skin Infection: Broadening the Scope of Type-Specific Immunity.

@article{Frost2017ImmuneCW,
  title={Immune Cross-Opsonization Within emm Clusters Following Group A Streptococcus Skin Infection: Broadening the Scope of Type-Specific Immunity.},
  author={Hannah R. C. Frost and Delphine Laho and Martina L. Sanderson-Smith and Paul Licciardi and Susan M. Donath and Nigel Curtis and Joseph H. Kado and James B Dale and Andrew C. Steer and Pierre Robert Smeesters},
  journal={Clinical infectious diseases : an official publication of the Infectious Diseases Society of America},
  year={2017},
  volume={65 9},
  pages={1523-1531}
}
Background Group A Streptococcus (GAS) skin infections are particularly prevalent in developing nations. The GAS M protein, by which strains are differentiated into >220 different emm types, is immunogenic and elicits protective antibodies. A major obstacle for vaccine development has been the traditional understanding that immunity following infection is… CONTINUE READING