Immune Cell Recruitment and Cell-Based System for Cancer Therapy

Abstract

Immune cells, such as cytotoxic T lymphocytes, natural killer cells, B cells, and dendritic cells, have a central role in cancer immunotherapy. Conventional studies of cancer immunotherapy have focused mainly on the search for an efficient means to prime/activate tumor-associated antigen-specific immunity. A systematic understanding of the molecular basis of the trafficking and biodistribution of immune cells, however, is important for the development of more efficacious cancer immunotherapies. It is well established that the basis and premise of immunotherapy is the accumulation of effective immune cells in tumor tissues. Therefore, it is crucial to control the distribution of immune cells to optimize cancer immunotherapy. Recent characterization of various chemokines and chemokine receptors in the immune system has increased our knowledge of the regulatory mechanisms of the immune response and tolerance based on immune cell localization. Here, we review the immune cell recruitment and cell-based systems that can potentially control the systemic pharmacokinetics of immune cells and, in particular, focus on cell migrating molecules, i.e., chemokines, and their receptors, and their use in cancer immunotherapy.

DOI: 10.1007/s11095-007-9443-9

Extracted Key Phrases

2 Figures and Tables

02040602008200920102011201220132014201520162017
Citations per Year

105 Citations

Semantic Scholar estimates that this publication has 105 citations based on the available data.

See our FAQ for additional information.

Cite this paper

@article{Gao2007ImmuneCR, title={Immune Cell Recruitment and Cell-Based System for Cancer Therapy}, author={Jianqing Gao and Naoki Okada and Tadanori Mayumi and Shinsaku Nakagawa}, journal={Pharmaceutical Research}, year={2007}, volume={25}, pages={752 - 768} }