Immune CD4+ T cells promote the clearance of influenza virus from major histocompatibility complex class II -/- respiratory epithelium.

@article{Topham1996ImmuneCT,
  title={Immune CD4+ T cells promote the clearance of influenza virus from major histocompatibility complex class II -/- respiratory epithelium.},
  author={David J. Topham and Ralph A Tripp and Sally R. Sarawar and Mark Y. Sangster and Peter C. Doherty},
  journal={Journal of virology},
  year={1996},
  volume={70 2},
  pages={1288-91}
}
The experiments described establish that CD4+ T-cell-dependent effector mechanisms can eliminate an H3N2 influenza A virus from lung cells that are unable to express class II major histocompatibility complex (MHC) glycoproteins. Radiation chimeras were made by using CD4+ T cells and bone marrow from CD8-depleted, MHC class II +/+ mice and irradiated (950 rads) MHC class II -/- recipients. The influenza virus-specific CD4+ T-cell responses in these +/+-->-/- mice were not obviously different… CONTINUE READING