Immune Activities of Polycationic Vectors for Gene Delivery

  title={Immune Activities of Polycationic Vectors for Gene Delivery},
  author={Xiaotian Zhao and Xiaoming Li and Yi Zhao and Yuan Cheng and Yunqi Yang and Zhiwei Fang and Yangmei Xie and Yao Liu and Yinghui Chen and Yuanming Ouyang and Weien Yuan},
  journal={Frontiers in Pharmacology},
Polycationic vectors are used widely in the field of gene delivery, while currently their immune activities in vivo are poorly understood. In this comprehensive review, we aim to present an overview of existing mechanisms of adverse immune responses induced by the polycation/gene complexes, which includes the polycations themselves, the gene sequences and the ROS produced by them. These causes can induce pro-inflammatory cytokines, hypersensitivity as well as the activation of toll-like… 

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