Immune Activation While on Potent Antiretroviral Therapy Can Predict Subsequent CD4+ T-Cell Increases Through 15 Years of Treatment.

@article{Zhang2013ImmuneAW,
  title={Immune Activation While on Potent Antiretroviral Therapy Can Predict Subsequent CD4+ T-Cell Increases Through 15 Years of Treatment.},
  author={Xinyan Zhang and Peter W. Hunt and Scott M. Hammer and Michelle S. Cespedes and Kristine B Patterson and Ronald J. Bosch},
  journal={HIV clinical trials},
  year={2013},
  volume={14 2},
  pages={61-7}
}
BACKGROUND While persistent T-cell activation has been cross-sectionally associated with poor CD4+ T-cell restoration in HIV-infected individuals maintaining antiretroviral treatment (ART)-mediated viral suppression, it remains unclear whether CD8+ T-cell activation is of predictive effect on CD4+ T-cell recovery. OBJECTIVE We assessed whether the extent of persistent CD8+ T-cell activation (% CD38+/HLA-DR+) in the first few years of ART-mediated viral suppression predicted subsequent CD4+ T… CONTINUE READING
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