Immune‐Modulating Effects of Melatonin, N‐Acetylserotonin, and N‐Acetyldopamine

@article{Perianayagam2005ImmuneModulatingEO,
  title={Immune‐Modulating Effects of Melatonin, N‐Acetylserotonin, and N‐Acetyldopamine},
  author={Mary C. Perianayagam and Gregory F Oxenkrug and Bertrand L. Jaber},
  journal={Annals of the New York Academy of Sciences},
  year={2005},
  volume={1053}
}
Abstract: Melatonin and N‐acetylserotonin (NAS) have antioxidant properties. In the present study, we examined whether melatonin, NAS, and N‐acetyldopamine (NAD) have a modulatory effect on tumor necrosis factor‐α (TNF‐α) synthesis and superoxide production. Differentiated THP‐1‐derived human monocytes were coincubated with Escherichia coli lipopolysaccharide (LPS) and rising concentrations of melatonin, NAS, or NAD. After 24 h, TNF‐α was measured in cell supernatants. In addition, the… 

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