Immune‐Modulating Effects of Melatonin, N‐Acetylserotonin, and N‐Acetyldopamine

  title={Immune‐Modulating Effects of Melatonin, N‐Acetylserotonin, and N‐Acetyldopamine},
  author={Mary C. Perianayagam and Gregory F Oxenkrug and Bertrand L. Jaber},
  journal={Annals of the New York Academy of Sciences},
Abstract: Melatonin and N‐acetylserotonin (NAS) have antioxidant properties. In the present study, we examined whether melatonin, NAS, and N‐acetyldopamine (NAD) have a modulatory effect on tumor necrosis factor‐α (TNF‐α) synthesis and superoxide production. Differentiated THP‐1‐derived human monocytes were coincubated with Escherichia coli lipopolysaccharide (LPS) and rising concentrations of melatonin, NAS, or NAD. After 24 h, TNF‐α was measured in cell supernatants. In addition, the… 

Effect of Methyl Derivatives of Dopamine on Tumor Necrosis Factor α and Lipid Peroxidation

The results indicated that the inhibitory effect of NAS, NAD, NMD, or 4‐O‐MD on LPS‐induced TNF‐α production and FeCl2‐stimulated lipid peroxidation is robust and dose dependent.

Melatonin and its metabolites ameliorate ultraviolet B‐induced damage in human epidermal keratinocytes

Melatonin, its precursor NAS, and its metabolites 6‐OHM, AFMK, 5‐MT, which are endogenously produced in keratinocytes, protect these cells against UVB‐induced oxidative stress and DNA damage.

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Effect of N‐Acetylserotonin on TLR‐4 and MyD88 Expression during Intestinal Ischemia‐Reperfusion in a Rat Model

  • I. SukhotnikY. B. Shahar A. Bitterman
  • Medicine, Biology
    European journal of pediatric surgery : official journal of Austrian Association of Pediatric Surgery ... [et al] = Zeitschrift fur Kinderchirurgie
  • 2019
Treatment with NAS is associated with downregulation of TLR‐4, MyD88, and TRAF6 expression along with a concomitant decrease in intestinal mucosal injury caused by intestinal IR in a rat.

Melatonin in macrophage biology: Current understanding and future perspectives

This review summarizes the current understanding of the significance of melatonin in macrophage biology and the beneficial effects ofmelatonin in Macrophage‐associated diseases and provides a better understanding about the importance ofMelatonin.

Serotonin and its metabolites reduce oxidative stress in murine RAW264.7 macrophages and prevent inflammation

Serotonin plays a key role in modulation of inflammation and the regulatory functions of immune cells, while also protecting cells against oxidative stress, and antioxidant capacity of tested compounds is a major advantage in the early stages of inflammation.

Metabolic Profile Reveals the Immunosuppressive Mechanisms of Methionyl-Methionine in Lipopolysaccharide-Induced Inflammation in Bovine Mammary Epithelial Cell

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N-acetylserotonin and aging-associated cognitive impairment and depression.

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Melatonin protects from ischemia/reperfusion‐induced renal injury in rats: this effect is not mediated by proinflammatory cytokines

The protective effect of melatonin on IR‐induced renal injury is related to its antioxidant properties but not to proinflammatory cytokines.

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This review of literature and our data suggests that up-regulated production of interferon-gamma (IFNG) in periphery and brain triggers a merger of tryptophan (TRY)–kynurenine (KYN) and



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Findings suggest that NAS inhibits the expression rather than the activity of iNOS in cultured macrophages and smooth muscle cells, which appears to be independent of the availability of BH4.

Melatonin as a therapeutic agent in experimental endotoxic shock

It is reported that a single melatonin injection protects mice treated with a lethal dose of lipolysaccharide especially when melatonin was injected 3 to 6 hr after LPS, and plasma nitrate concentration, which reflects the rate of NO synthesis, showed a significant reduction at 18 and 24 hr afterLPS administration.

Effects of melatonin on the expression of iNOS and COX-2 in rat models of colitis.

Melatonin has a protective effect on colonic injury induced by both acetic acid and TNBS enemas, which is probably via a mechanism of local inhibition of iNOS and COX-2 expression in colonic mucosa.

Melatonin reduces oxidative stress in surgical neonates.

Suppressive effect of melatonin administration on ethanol‐induced gastroduodenal injury in rats in vivo

Melatonin ameliorated both the decrease in tGSH concentration as well as the reduction of GSSG‐Rd activity elicited by ethanol both in the stomach and duodenum; melatonin was effective against indomethacin‐ethanol‐induced damage only in theomach, and ethanol‐induced gastroduodenal damage is believed to be mediated by the generation of free radicals.