Immortalized pathological human myoblasts: towards a universal tool for the study of neuromuscular disorders

@inproceedings{Mamchaoui2011ImmortalizedPH,
  title={Immortalized pathological human myoblasts: towards a universal tool for the study of neuromuscular disorders},
  author={Kamel Mamchaoui and Capucine Trollet and Anne Bigot and Elisa Negroni and Soraya Chaouch and Annie Wolff and Prashanth Kumar Kandalla and Solenne Marie and James P Di Santo and Jean Lacau St Guily and Francesco Muntoni and Jihee Kim and Susanne Philippi and Simone Spuler and Nicolas L{\'e}vy and Sergiu C. Blumen and Thomas Voit and Woodring E Wright and Ahmed Aamiri and Gillian Butler-Browne and Vincent Mouly},
  booktitle={Skeletal Muscle},
  year={2011}
}
Investigations into both the pathophysiology and therapeutic targets in muscle dystrophies have been hampered by the limited proliferative capacity of human myoblasts. Isolation of reliable and stable immortalized cell lines from patient biopsies is a powerful tool for investigating pathological mechanisms, including those associated with muscle aging, and for developing innovative gene-based, cell-based or pharmacological biotherapies. Using transduction with both telomerase-expressing and… CONTINUE READING
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