Immortalized neural stem cells differ from nonimmortalized cortical neurospheres and cerebellar granule cell progenitors.

@article{Mi2005ImmortalizedNS,
  title={Immortalized neural stem cells differ from nonimmortalized cortical neurospheres and cerebellar granule cell progenitors.},
  author={Ruifa Mi and Yongquan Luo and Jingli Cai and Tobi L. Limke and Mahendra S. Rao and Ahmet H{\"o}ke},
  journal={Experimental neurology},
  year={2005},
  volume={194 2},
  pages={301-19}
}
Pluripotent neural stem cells (NSCs) have been used as replacement cells in a variety of neurological disease models. Among the many different NSCs that have been used to date, most robust results have been obtained with the immortalized neural stem cell line (C17.2) isolated from postnatal cerebellum. However, it is unclear if other NSCs isolated from different brain regions are similar in their potency as replacement therapies. To assess the properties of NSC-like C17.2 cells, we compared the… CONTINUE READING