Immortalized neural progenitor cells for CNS gene transfer and repair

  title={Immortalized neural progenitor cells for CNS gene transfer and repair},
  author={Alberto Mart{\'i}nez-Serrano and Anders Bj{\"o}rklund},
  journal={Trends in Neurosciences},
Immortalized multipotent neural stem and progenitor cells have emerged as a highly convenient source of tissue for genetic manipulation and ex vivo gene transfer to the CNS. Recent studies show that these cells, which can be maintained and genetically transduced as cell lines in culture, can survive, integrate and differentiate into both neurons and glia after transplantation to the intact or damaged brain. Progenitors engineered to secrete trophic factors, or to produce neurotransmitter… CONTINUE READING

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