Immortalized goat milk epithelial cell lines replicate CAEV at high level.

  title={Immortalized goat milk epithelial cell lines replicate CAEV at high level.},
  author={Laila Mselli-Lakhal and François Guiguen and Claudie Fornazero and Colette Favier and Jitka Durand and D{\'e}lphine Grezel and Ahmed Moussa and Jean François Mornex and Yahia Chebloune},
  journal={Veterinary research},
  volume={32 5},
Primary milk epithelial cells were isolated from CAEV-uninfected goats and three cell lines designated TIGMEC-1, TIGMEC-2 and TIGMEC-3 were established. The three cell lines retained their morphological characteristics of epithelial cells and expressed specific epithelial cytokeratin marker as well as the immortalizing SV40 large T antigen. The kinetics of growth of TIGMEC1, TIGMEC2 and TIGMEC3 cell lines showed a doubling time of 24-48 hours while the parental cell lines became senescent after… CONTINUE READING
8 Citations
41 References
Similar Papers


Publications citing this paper.
Showing 1-8 of 8 extracted citations


Publications referenced by this paper.
Showing 1-10 of 41 references

Goat milk epithelial cells are highly permissive to CAEV infection, Virology

  • L. Mselli-Lakhal, F. Guiguen, +6 authors Y. Chebloune
  • 1999
Highly Influential
4 Excerpts

Biological characterization of the virus causing leukoencephalitis and arthritis in goats

  • O. Narayan, E. ClementsJ., D. StrandbergJ., C. CorkL., E. GriffinD.
  • J . Virol .
  • 2000

Similar Papers

Loading similar papers…