Immortalized fibroblast-like cells derived from human embryonic stem cells support undifferentiated cell growth.

@article{Xu2004ImmortalizedFC,
  title={Immortalized fibroblast-like cells derived from human embryonic stem cells support undifferentiated cell growth.},
  author={Chunhui Xu and Jianjie Jiang and Virginie Sottile and Jim McWhir and Jane S Lebkowski and Melissa K. Carpenter},
  journal={Stem cells},
  year={2004},
  volume={22 6},
  pages={972-80}
}
Human embryonic stem cells (hESCs) have the potential to generate multiple cell types and hold promise for future therapeutic applications. Although undifferentiated hESCs can proliferate indefinitely, hESC derivatives significantly downregulate telomerase and have limited replication potential. In this study we examine whether the replicative lifespan of hESC derivatives can be extended by ectopic expression of human telomerase reverse transcriptase (hTERT), the catalytic component of the… CONTINUE READING

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