Immortalized Mouse Inner Ear Cell Lines Demonstrate a Role for Chemokines in Promoting the Growth of Developing Statoacoustic Ganglion Neurons

@article{Bianchi2005ImmortalizedMI,
  title={Immortalized Mouse Inner Ear Cell Lines Demonstrate a Role for Chemokines in Promoting the Growth of Developing Statoacoustic Ganglion Neurons},
  author={Lynne M. Bianchi and Zeeba R Daruwalla and Therese M. Roth and Naweah P. Attia and Nicholas W Lukacs and Ayo-Lynn Richards and Ian O. White and Susan J Allen and Kate F. Barald},
  journal={Journal of the Association for Research in Otolaryngology},
  year={2005},
  volume={6},
  pages={355-367}
}
The target-derived factors necessary for promoting initial outgrowth from the statoacoustic ganglion (SAG) to the inner ear have not been fully characterized. In the present study, conditioned medium from embryonic Immortomouse inner ear cell lines that maintain many characteristics of developing inner ear sensory epithelia were screened for neurite-promoting activity. Conditioned medium found to be positive for promoting SAG neurite outgrowth and neuronal survival was then tested for the… CONTINUE READING