Immortalized Human HaCaT Keratinocytes Mitochondrial Apoptosis Pathway by Sanguinarine in Activation of Prodeath Bcl-2 Family Proteins and Updated Version

@inproceedings{Adhami2003ImmortalizedHH,
  title={Immortalized Human HaCaT Keratinocytes Mitochondrial Apoptosis Pathway by Sanguinarine in Activation of Prodeath Bcl-2 Family Proteins and Updated Version},
  author={Vaqar Mustafa Adhami and Moammir H Aziz and Hasan Mukhtar and Nihal Ahmad},
  year={2003}
}
Sanguinarine, derived from the root of Sanguinaria canadensis and other poppy fumaria species, possesses strong antimicrobial, anti-inflammatory, and antioxidant properties. We earlier showed that sanguinarine kills human epidermoid carcinoma A431 cells via an induction of apoptosis [N. Ahmad et al., Clin. Cancer Res., 6: 1524–1528, 2000]. In this study, using immortalized human keratinocytes (HaCaT cells), we provide information about mechanism of the antiproliferative effect of sanguinarine… CONTINUE READING

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