Immortalized B lymphocytes produce B-cell growth factor.

Abstract

The activation, clonal expansion and terminal differentiation of small resting B lymphocytes primed by an antigen (or antibodies to its receptors) appear to follow an orderly developmental sequence triggered at each stage by distinct soluble cytokines, primarily produced by T lymphocytes. For man, the only known B-cell mitogen independent of accessory cells… (More)

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