Immortalization of human lymphocytes by Epstein-Barr virus.

  title={Immortalization of human lymphocytes by Epstein-Barr virus.},
  author={George Miller},
  journal={The Yale Journal of Biology and Medicine},
  pages={305 - 310}
  • George Miller
  • Published 1982 in The Yale journal of biology and medicine
Epstein-Barr virus (EBV) confers upon normal lymphocytes derived from bone marrow the ability to proliferate indefinitely in a test tube. This process, called immortalization, is crucial to the pathogenesis of EBV infections. Inside the immortalized lymphocyte the EBV genome exists as a complete multicopy circular plasmid which is probably not integrated into the cell chromosome. Most of the viral genetic information is not expressed. However, at least six to eight separate regions of the EBV… CONTINUE READING

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The DNA of Epstein - Barr virus is amplified in transformed lymphocytes

M Phelps
J Virol • 1981

Epstein - Barr virus RNA VII : Size and direction of transcription of virusspecified cytoplasmic RNAs in a transformed cell line

A Cheung
Proc Natl Acad Sci USA • 1976

Human lymphoblastoid cell lines and Epstein - Barr virus ( A review of their interrelationships and their relevance to the etiology of leukoproliferative states in man )

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