Immortalization of human esophageal keratinocytes by E6 and E7 of human papillomavirus type 16.

@article{Sashiyama2001ImmortalizationOH,
  title={Immortalization of human esophageal keratinocytes by E6 and E7 of human papillomavirus type 16.},
  author={Hiroshi Sashiyama and Yuji Shino and Yasutaka Kawamata and Yasuhiko Tomita and Narihito Ogawa and Hideaki Shimada and Seiichiro Kobayashi and Tomoichiro Asano and Takenori Ochiai and Hiroshi Shirasawa},
  journal={International journal of oncology},
  year={2001},
  volume={19 1},
  pages={97-103}
}
Transduction of human papillomavirus type 16 (HPV16) E6/E7 into primary culture of human esophageal keratinocytes using a recombinant adenovirus prolonged the life-span, while untreated cells senesced within 14-16 population doublings (PDLs). Up-regulation of telomerase activity and acquisition of serum-resistant growth were observed in the esophageal keratinocytes with extended life-span between 50 and 100 PDLs, and drastically increased after 100 PDLs. A keratinocyte sample with a… CONTINUE READING

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 13 extracted citations

Similar Papers

Loading similar papers…