Immortalization of human cells and their malignant conversion by high risk human papillomavirus genotypes.

@article{Hausen1999ImmortalizationOH,
  title={Immortalization of human cells and their malignant conversion by high risk human papillomavirus genotypes.},
  author={Harald zur Hausen},
  journal={Seminars in cancer biology},
  year={1999},
  volume={9 6},
  pages={405-11}
}
Papillomaviruses cause certain common human cancers, most notably carcinoma of the cervix. The viral oncoproteins E6 and E7 are essential components in malignant conversion, although, in spite of being necessary, they are not sufficient for the development of the malignant phenotype. High risk HPV oncogenes fulfill dual functions in genome-harboring cells: their derived oncoproteins stimulate cell growth by pleiotropic effects. At the same time they act as progression factors by inducing… CONTINUE READING