Immortalization of epithelial progenitor cells mediated by resveratrol

@article{Pearce2008ImmortalizationOE,
  title={Immortalization of epithelial progenitor cells mediated by resveratrol},
  author={Virginia P Pearce and John Sherrell and Zhenjun Lou and Levy Kopelovich and Woodring E. Wright and Jerry W. Shay},
  journal={Oncogene},
  year={2008},
  volume={27},
  pages={2365-2374}
}
Within the hierarchy of epithelial stem cells, normal progenitor cells may express regulated telomerase during renewal cycles of proliferation and differentiation. Discontinuous telomerase activity may promote increased renewal capacity of progenitor cells, while deregulated/continuous telomerase activity may promote immortalization when differentiation and/or senescent pathways are compromised. In the present work, we show that resveratrol activates, while progesterone inactivates, continuous… 
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Therapeutic Targeting of Telomerase
TLDR
Novel vector systems have been developed for a ‘mild’ integration of telomerase into the host genome and loss of the vector in rapidly-proliferating cells, currently unclear if this technique can be used in human beings to treat chronic diseases, such as atherosclerosis.
Effects of resveratrol on the proliferation, apoptosis and telomerase ability of human A431 epidermoid carcinoma cells
TLDR
Resveratrol is capable of downregulating the expression of hTERT protein and inhibits the ability of telomerase of A431, which is an important mechanism of action of resver atrol with regard to inhibition of A430 cell proliferation.
Potential of Naturally Derived Compounds in Telomerase and Telomere Modulation in Skin Senescence and Aging
TLDR
The metabolic potential of natural compounds to modulate telomerase and telomere biology and thus prevent senescence and skin aging is focused on.
Possibilities and effects of telomerase activation
TLDR
It is emphasized that elevated hTERT expression may cause cell malignant transformation, especially in the case of h TERT transfection, and this possibility must be considered when choosing the means of telomerase activation for therapeutic purposes.
Chemical and Physical Approaches to Extend the Replicative and Differentiation Potential of Stem Cells
TLDR
Certain strategies and known underlying mechanisms are introduced in this review, with an evaluation of their pros and cons in order to facilitate safe and effective MSC expansion ex vivo.
Regulation of the Telomerase Reverse Transcriptase Subunit through Epigenetic Mechanisms
TLDR
This work has shown that an epigenetics diet that can affect the epigenome of cancer cells is a recent fascination that has received much attention, and by combining portions of this diet with epigenome-altering treatments, it is possible to selectively regulate the epigenetic control of hTERT and its expression.
Mesenchymal Stem Cell-Based Cartilage Regeneration Approach and Cell Senescence: Can We Manipulate Cell Aging and Function?
TLDR
Homeostasis alterations occurring in MSC-derived chondrocytes during in vitro aging are focused on and potential cell aging regulation approaches, such as cell stimulation through telomerase activators, mechanical strain, and epigenetic regulation are dealt with.
Disruptive chemicals, senescence and immortality.
TLDR
The possible mechanisms of cellular immortalization, the contribution of immortalization to tumorigenesis and the mechanisms by which chemical carcinogens may contribute to these processes are explored.
Disruptive chemicals, senescence and immortality
TLDR
This work has shown that clonal evolution involves the repeated ‘selection and succession’ of rare variant cells that acquire a growth advantage over the remaining cell population through the acquisition of ‘driver mutations’ enabling a selective advantage in a particular micro-environment.
Ascorbic Acid Attenuates Senescence of Human Osteoarthritic Osteoblasts
The accumulation of senescent cells is implicated in the pathology of several age-related diseases. While the clearance of senescent cells has been suggested as a therapeutic target for patients with…
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