Immortalization of epithelial progenitor cells mediated by resveratrol

  title={Immortalization of epithelial progenitor cells mediated by resveratrol},
  author={Virginia P Pearce and John Sherrell and Zhenjun Lou and Levy Kopelovich and Woodring E. Wright and Jerry W. Shay},
Within the hierarchy of epithelial stem cells, normal progenitor cells may express regulated telomerase during renewal cycles of proliferation and differentiation. Discontinuous telomerase activity may promote increased renewal capacity of progenitor cells, while deregulated/continuous telomerase activity may promote immortalization when differentiation and/or senescent pathways are compromised. In the present work, we show that resveratrol activates, while progesterone inactivates, continuous… 
Therapeutic Targeting of Telomerase
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Possibilities and effects of telomerase activation
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Chemical and Physical Approaches to Extend the Replicative and Differentiation Potential of Stem Cells
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Regulation of the Telomerase Reverse Transcriptase Subunit through Epigenetic Mechanisms
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Mesenchymal Stem Cell-Based Cartilage Regeneration Approach and Cell Senescence: Can We Manipulate Cell Aging and Function?
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Disruptive chemicals, senescence and immortality.
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Disruptive chemicals, senescence and immortality
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Ascorbic Acid Attenuates Senescence of Human Osteoarthritic Osteoblasts
The accumulation of senescent cells is implicated in the pathology of several age-related diseases. While the clearance of senescent cells has been suggested as a therapeutic target for patients with


Dissociation among in vitro telomerase activity, telomere maintenance, and cellular immortalization.
It is shown that ectopic expression of the telomerase catalytic subunit (human telomersase reverse transcriptase or hTERT) and subsequent activation of telomer enzyme can allow postsenescent cells to proliferate beyond crisis, the last known proliferative blockade to cellular immortality.
Role of telomerase in cellular proliferation and cancer
Telomerase is a cellular reverse transcriptase that helps to provide genomic stability in highly proliferative normal, immortal, and tumor cells by maintaining the integrity of the chromosome ends,
Molecular changes accompanying senescence and immortalization of cultured human mammary epithelial cells.
Events in the immortalizing process of primary human mammary epithelial cells by the catalytic subunit of human telomerase.
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High susceptibility of a human breast epithelial cell type with stem cell characteristics to telomerase activation and immortalization.
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Telomerase Maintains Telomere Structure in Normal Human Cells
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Loss of p53 function accelerates acquisition of telomerase activity in indefinite lifespan human mammary epithelial cell lines
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