Immortalization of epithelial progenitor cells mediated by resveratrol

@article{Pearce2008ImmortalizationOE,
  title={Immortalization of epithelial progenitor cells mediated by resveratrol},
  author={Virginia P Pearce and John Sherrell and Zhenjun Lou and Levy Kopelovich and Woodring E. Wright and Jerry W. Shay},
  journal={Oncogene},
  year={2008},
  volume={27},
  pages={2365-2374}
}
Within the hierarchy of epithelial stem cells, normal progenitor cells may express regulated telomerase during renewal cycles of proliferation and differentiation. Discontinuous telomerase activity may promote increased renewal capacity of progenitor cells, while deregulated/continuous telomerase activity may promote immortalization when differentiation and/or senescent pathways are compromised. In the present work, we show that resveratrol activates, while progesterone inactivates, continuous… 
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