Immortalization of distinct human mammary epithelial cell types by human papilloma virus 16 E6 or E7.

@article{Wazer1995ImmortalizationOD,
  title={Immortalization of distinct human mammary epithelial cell types by human papilloma virus 16 E6 or E7.},
  author={David E. Wazer and Xiao Liu and Qian Chu and Qingshen Gao and Vimla Band},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1995},
  volume={92 9},
  pages={3687-91}
}
Multiple mammary epithelial cell (MEC) types are observed both in mammary ducts in vivo and in primary cultures in vitro; however, the oncogenic potential of different cell types remains unknown. Here, we used human papilloma virus 16 E6 and E7 oncogenes, which target p53 and Rb tumor suppressor proteins, respectively, to immortalize MECs present in early or late passages of human mammary tissue-derived cultures or in milk. One MEC subtype was exclusively immortalized by E6; such cells… CONTINUE READING

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