Immortalization of Human Cells and Induction of DNA Synthesis in Heterokaryons

@article{Yegorov2002ImmortalizationOH,
  title={Immortalization of Human Cells and Induction of DNA Synthesis in Heterokaryons},
  author={Ye. E. Yegorov and E. V. Kazimirchuk and Sergey M Terekhov and Dmitry N. Karachentsev and Kh. S. Vishnyakova and Yu. A. Meshcheryakova and Alexandr V. Zelenin},
  journal={Molecular Biology},
  year={2002},
  volume={36},
  pages={74-75}
}
Heterokaryons are hybrid cells formed by fusion of two different cells and containing two nuclei. We have been demonstrated earlier that in heterokaryons formed by fusion of different proliferating cells and mouse macrophages, DNA synthesis in macrophage nuclei is reactivated only upon fusion with immortal cells [1–4]. A hypothesis arose that telomerase is required for reactivation of DNA synthesis in macrophage nuclei. The present work was done to check the hypothesis. 
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Role of Telomerase in Reactivation of Macrophage Nuclei in Heterokaryons

  • Russian Journal of Developmental Biology
  • 2005
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