Immortalization eliminates a roadblock during cellular reprogramming into iPS cells

@article{Utikal2009ImmortalizationEA,
  title={Immortalization eliminates a roadblock during cellular reprogramming into iPS cells},
  author={Jochen Utikal and Jose M Polo and Matthias Stadtfeld and Nimet Maherali and Warakorn Kulalert and Ryan Walsh and Adam Khalil and James G. Rheinwald and Konrad Hochedlinger},
  journal={Nature},
  year={2009},
  volume={460},
  pages={1145-1148}
}
The overexpression of defined transcription factors in somatic cells results in their reprogramming into induced pluripotent stem (iPS) cells. The extremely low efficiency and slow kinetics of in vitro reprogramming suggest that further rare events are required to generate iPS cells. The nature and identity of these events, however, remain elusive. We… CONTINUE READING