Immortality of cell lines: challenges and advantages of establishment

@article{IrfanMaqsood2013ImmortalityOC,
  title={Immortality of cell lines: challenges and advantages of establishment},
  author={Muhammad Irfan Maqsood and Maryam M. Matin and Ahmad Reza Bahrami and Mohammad Mousaei Ghasroldasht},
  journal={Cell Biology International},
  year={2013},
  volume={37}
}
Cellular immortality happens upon impairment of cell‐cycle checkpoint pathways (p53/p16/pRb), reactivation or up‐regulation of telomerase enzyme, or upregulation of some oncogenes or oncoproteins leading to a higher rate of cell division.There are also some other factors and mechanisms involved in immortalisation, which need to be discovered. Immortalisation of cells derived from different sources and establishment of immortal cell lines has proven useful in understanding the molecular pathways… Expand
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