Immobilized lactoferrin is a stimulus for eosinophil activation.

  title={Immobilized lactoferrin is a stimulus for eosinophil activation.},
  author={Larry L. Thomas and Wei Xu and Tamir T. Ardon},
  journal={Journal of immunology},
  volume={169 2},
Eosinophils are strongly implicated in the pathogenesis of asthma, particularly in damage to the airway epithelial lining. We examined the potential for lactoferrin, a multifunctional glycoprotein present in the airway surface liquid, to activate eosinophils. Incubating eosinophils in tissue culture wells pretreated with 1-100 microg/ml human lactoferrin stimulated concentration-dependent superoxide production by eosinophils. The same concentrations of immobilized transferrin were without… CONTINUE READING


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