Immobilized lactoferrin is a stimulus for eosinophil activation.

@article{Thomas2002ImmobilizedLI,
  title={Immobilized lactoferrin is a stimulus for eosinophil activation.},
  author={Larry L. Thomas and Wei Xu and Tamir T. Ardon},
  journal={Journal of immunology},
  year={2002},
  volume={169 2},
  pages={993-9}
}
Eosinophils are strongly implicated in the pathogenesis of asthma, particularly in damage to the airway epithelial lining. We examined the potential for lactoferrin, a multifunctional glycoprotein present in the airway surface liquid, to activate eosinophils. Incubating eosinophils in tissue culture wells pretreated with 1-100 microg/ml human lactoferrin stimulated concentration-dependent superoxide production by eosinophils. The same concentrations of immobilized transferrin were without… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 11 extracted citations

Neutrophils and asthma.

Journal of investigational allergology & clinical immunology • 2009
View 3 Excerpts

Lactoferrin, a major defense protein of innate immunity, is a novel maturation factor for human dendritic cells.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology • 2008

Similar Papers

Loading similar papers…