Immobilized concentration gradients of neurotrophic factors guide neurite outgrowth of primary neurons in macroporous scaffolds.

@article{Moore2006ImmobilizedCG,
  title={Immobilized concentration gradients of neurotrophic factors guide neurite outgrowth of primary neurons in macroporous scaffolds.},
  author={Kathryn J. Moore and Margaret MacSween and Molly S Shoichet},
  journal={Tissue engineering},
  year={2006},
  volume={12 2},
  pages={267-78}
}
Neurotrophic factors present as concentration gradients are neurotropic cues that direct axonal growth toward their targets. Multiple factors work together in vivo to ensure axons reach the proper targets, likely interacting with one another via intracellular signalling pathways. Nerve growth factor (NGF) and neurotrophin-3 (NT-3) are neurotrophins known to guide axons as well as promote axonal growth following injury to both the spinal cord and peripheral nerve. These molecules interact with… CONTINUE READING

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