Immobilized chemokine fields and soluble chemokine gradients cooperatively shape migration patterns of dendritic cells.

@article{Schumann2010ImmobilizedCF,
  title={Immobilized chemokine fields and soluble chemokine gradients cooperatively shape migration patterns of dendritic cells.},
  author={Kathrin Schumann and Tim Laemmermann and Markus Bruckner and Daniel F Legler and Julien Polleux and Joachim P Spatz and Gerold Schuler and Reinhold Foerster and Manfred B Lutz and Lydia Sorokin and Michael Sixt},
  journal={Immunity},
  year={2010},
  volume={32 5},
  pages={703-13}
}
Chemokines orchestrate immune cell trafficking by eliciting either directed or random migration and by activating integrins in order to induce cell adhesion. Analyzing dendritic cell (DC) migration, we showed that these distinct cellular responses depended on the mode of chemokine presentation within tissues. The surface-immobilized form of the chemokine CCL21, the heparan sulfate-anchoring ligand of the CC-chemokine receptor 7 (CCR7), caused random movement of DCs that was confined to the… CONTINUE READING
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