Immobilization on Metal-Organic Framework Engenders High Sensitivity for Enzymatic Electrochemical Detection.

@article{Zhang2017ImmobilizationOM,
  title={Immobilization on Metal-Organic Framework Engenders High Sensitivity for Enzymatic Electrochemical Detection.},
  author={Cheng Zhang and Xuerui Wang and Miao Hou and Xiaoyang Li and Xiaoling Wu and Jun Ge},
  journal={ACS applied materials & interfaces},
  year={2017},
  volume={9 16},
  pages={
          13831-13836
        }
}
The protection effect of metal-organic framework (MOF) provides high stability for immobilized enzyme. The small cavities of MOFs, however, usually result in decreased apparent substrate affinity and enzymatic activity of immobilized enzyme, compared to native enzyme. We synthesized zeolitic imidazolate framework-8 (ZIF-8) with a combination of mesoporous and microporous channels for cytochrome c (Cyt c) immobilization. Compared with native Cyt c, the immobilized Cyt c displayed increased… CONTINUE READING