Immobilization of glycosylphosphatidylinositol-anchored proteins inhibits T cell growth but not function.

@article{Marmor1999ImmobilizationOG,
  title={Immobilization of glycosylphosphatidylinositol-anchored proteins inhibits T cell growth but not function.},
  author={Mina D Marmor and M F Bachmann and Pamela S Ohashi and Thomas R Malek and Michael Julius},
  journal={International immunology},
  year={1999},
  volume={11 9},
  pages={1381-93}
}
Accumulating evidence suggests that proteins tethered to the plasma membrane through glycosylphosphatidylinositol (GPI) anchors share common biological properties. In the present study we demonstrate that GPI-anchored proteins regulate T cell growth. Specifically, anti-TCR-induced proliferation was profoundly inhibited by co-immobilized mAb specific for Thy-1, CD48 and Ly6A/E. However, neither IL-2 production nor the effector function of cytotoxic T lymphocytes was impaired in these… CONTINUE READING
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