Immobilization of ibuprofen and copper-ibuprofen drugs on layered double hydroxides.

@article{Gordijo2005ImmobilizationOI,
  title={Immobilization of ibuprofen and copper-ibuprofen drugs on layered double hydroxides.},
  author={Claudia R. Gordijo and C{\'e}sar A S Barbosa and Ana Maria da Costa Ferreira and Vera Regina Leopoldo Constantino and Denise de Oliveira Silva},
  journal={Journal of pharmaceutical sciences},
  year={2005},
  volume={94 5},
  pages={1135-48}
}
The immobilization of the NSAID ibuprofen (Hibp) and the Cu(II)-ibp compound on magnesium-aluminum layered double hydroxides (Mg3Al-LDH) is described. Ibuprofen was intercalated on LDHs by three routes (ion exchange, co-precipitation, and reconstruction). The organic drug and the Cu(II)-ibp were also immobilized by adsorption on LDH external surfaces. Materials were characterized by elemental analysis, UV/VIS, FTIR, and Raman spectroscopies, powder X-ray diffractometry (XRD), thermogravimetry… CONTINUE READING