Immobilization of human thrombomodulin on biomaterials: evaluation of the activity of immobilized human thrombomodulin.

@article{Kishida1994ImmobilizationOH,
  title={Immobilization of human thrombomodulin on biomaterials: evaluation of the activity of immobilized human thrombomodulin.},
  author={Akio Kishida and Yoshio Ueno and Ikuro Maruyama and Mitsuru Akashi},
  journal={Biomaterials},
  year={1994},
  volume={15 14},
  pages={
          1170-4
        }
}
Thrombomodulin (TM) is a newly described endothelial cell associated protein that functions as a potent natural anticoagulant by converting thrombin from a procoagulant protease to an anticoagulant. In this study, the immobilization of hTM was investigated in detail using surface modified polymers. As the basis of immobilization, poly(acrylic acid) (PAAc) surface-grafted poly(ethylene) (PAAc-g-PE) film was used with the expectation of increasing the immobilization amount of hTM. The effect of… CONTINUE READING