Immobilization of heparin on a silicone surface through a heterobifunctional PEG spacer.

@article{Chen2005ImmobilizationOH,
  title={Immobilization of heparin on a silicone surface through a heterobifunctional PEG spacer.},
  author={Hong Chen and Yang Chen and Heather D Sheardown and Michael A Brook},
  journal={Biomaterials},
  year={2005},
  volume={26 35},
  pages={7418-24}
}
A novel method of immobilizing heparin on a silicone surface through a heterobifunctional PEG spacer was used yield well defined surfaces with highly active surface immobilized heparin and low non-specific protein adsorption. The heparin surface density achieved using this technique was 0.68 microg/cm2. Sessile drop water contact angles showed increased hydrophilicity of the silicone surface after PEG modification and a further decrease in the contact angles following the grafting of heparin… CONTINUE READING