Immobility induced by forced swimming in rats: effects of agents which modify central catecholamine and serotonin activity.

@article{Porsolt1979ImmobilityIB,
  title={Immobility induced by forced swimming in rats: effects of agents which modify central catecholamine and serotonin activity.},
  author={Roger D. Porsolt and Alberta Bertin and Nadine Blavet and M Deniel and Maurice Jalfre},
  journal={European journal of pharmacology},
  year={1979},
  volume={57 2-3},
  pages={
          201-10
        }
}
Rats were forced to swim in a restricted space will rapidly cease apparent attempts to escape and adopt a characteristic posture which we have termed "immobility". We show in previous experiments that immobility was reduced by a variety of antidepressant agents and thus suggested that the method could serve as a screening model for antidepressants. The present experiments showed that immobility was reduced by drugs which increase central dopaminergic and alpha-adrenergic activity but was less… CONTINUE READING

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