Immobilisation on polystyrene of diazirine derivatives of mono- and disaccharides: biological activities of modified surfaces.

@article{Chevolot2001ImmobilisationOP,
  title={Immobilisation on polystyrene of diazirine derivatives of mono- and disaccharides: biological activities of modified surfaces.},
  author={Yann Chevolot and Jacob Martins and Nela Milo{\vs}evi{\'c} and Didier L{\'e}onard and Su Zeng and Martine Malissard and Eric Guevara Berger and Peter Maier and Hans Jorg Mathieu and David H. G. Crout and Hans Sigrist},
  journal={Bioorganic & medicinal chemistry},
  year={2001},
  volume={9 11},
  pages={
          2943-53
        }
}
The potential of surface glycoengineering for biomaterials and biosensors originates from the importance of carbohydrate-protein interactions in biological systems. The strategy employed here utilises carbene generated by illumination of diazirine to achieve covalent bonding of carbohydrates. Here, we describe the synthesis of an aryl diazirine containing a disaccharide (lactose). Surface analysis techniques [X-ray photoelectron spectroscopy (XPS) and time of flight secondary ion mass… CONTINUE READING

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