Immediate upregulation of proteins belonging to different branches of the apoptotic cascade in the retina after optic nerve transection and optic nerve crush.

@article{Agudo2009ImmediateUO,
  title={Immediate upregulation of proteins belonging to different branches of the apoptotic cascade in the retina after optic nerve transection and optic nerve crush.},
  author={Marta Agudo and Maria Cruz P{\'e}rez-Mar{\'i}n and Paloma Sobrado-Calvo and Ulrika L{\"o}nngren and Manuel Salinas-Navarro and Isabel C{\'a}novas and Francisco M Nadal-Nicol{\'a}s and Jaime Miralles-Imperial and Finn Hallb{\"o}{\"o}k and Manuel Vidal-Sanz},
  journal={Investigative ophthalmology & visual science},
  year={2009},
  volume={50 1},
  pages={424-31}
}
PURPOSE To further investigate the molecular signals underlying optic nerve (ON) injury, the authors analyzed in adult control, ON-transected, and ON-crushed retinas the expression pattern and time-course regulation of the following proteins, all of which are linked to apoptosis through different pathways: Stat 1, caspase 11 (inflammation and death), cathepsins C and B (lysosomal death pathway), calpain 1 (endoplasmic reticulum stress), calreticulin (apoptosis marker), Jun (early response), and… CONTINUE READING