Immediate treatment with propranolol decreases posttraumatic stress disorder two months after trauma

  title={Immediate treatment with propranolol decreases posttraumatic stress disorder two months after trauma},
  author={Guillaume Vaiva and François Ducrocq and Karine Jezequel and Beno{\^i}t Averland and Philippe Lestavel and Alain Brunet and Charles R Marmar},
  journal={Biological Psychiatry},

Tables from this paper

Does Acute Propranolol Treatment Prevent Posttraumatic Stress Disorder, Anxiety, and Depression in Children with Burns?
The prevalence of PTSD, anxiety, and depression was similar in children who received propranolol acutely and those who did not, and may be influenced by the standard of care that all children received timely pharmacotherapy for pain and anxiety management and psychotherapy beginning in their acute phase of treatment.
Propranolol does not reduce risk for acute stress disorder in pediatric burn trauma.
Propranolol was not found to influence the risk for subsequent ASD, in contrast to the observed benefit of proPRanolol reported in other studies with different at risk populations.
Propranolol's impact on cognitive performance in post-traumatic stress disorder.
The role of propranolol for post-exposure chemoprophylaxis of posttraumatic stress disorder and acute stress disorder
Current data suggest ineffectiveness of propranolol for this indication, but larger, randomized, placebo-controlled trials that include more diverse types of traumas are needed in order to provide more definitive evidence.
Prevention of posttraumatic stress disorder by early treatment: results from the Jerusalem Trauma Outreach And Prevention study.
Prolonged exposure, CT, and delayed PE effectively prevent chronic PTSD in recent survivors, and the lack of improvement from treatment with escitalopram requires further evaluation.
Posttraumatic Stress Disorder and Pain Impact Functioning and Disability After Major Burn Injury
Assessing PTSD and pain following burn injury may aid in predicting future functioning, and future work should confirm this and evaluate whether aggressively treating both PTSD andPain helps improve functioning after major burn injury.
Effect of Acute Posttrauma Propranolol on PTSD Outcome and Physiological Responses During Script‐Driven Imagery
The physiological results provide some limited support for a model of PTSD in which a traumatic conditioned response is reduced by posttrauma propranolol, however, the clinical results from this study do not support the preventive use of proPRanolol in the acute aftermath of a traumatic event.


Pilot study of secondary prevention of posttraumatic stress disorder with propranolol
A prospective study of psychophysiological arousal, acute stress disorder, and posttraumatic stress disorder.
This study investigated the role of acute arousal in the development of posttraumatic stress disorder (PTSD) and found that participants who developed PTSD had higher HR in the acute posttrauma phase than those without PTSD.
A prospective study of heart rate response following trauma and the subsequent development of posttraumatic stress disorder.
Elevated heart rate shortly after trauma is associated with the later development of posttraumatic stress disorder (PTSD).
De novo conditioning in trauma-exposed individuals with and without posttraumatic stress disorder.
Differential conditioning was assessed in 15 medication-free individuals meeting Diagnostic and Statistical Manual of Mental Disorders criteria for chronic posttraumatic stress disorder and 18 trauma-exposed individuals who never developed PTSD (non-PTSD).
Emergency Room Vital Signs and PTSD in a Treatment Seeking Sample of Motor Vehicle Accident Survivors
Those with elevated HRs in the ED were significantly less likely to meet criteria for PTSD 13 months post-MVA and that those with elevatedHRs had lower levels of posttraumatic stress symptoms, while those with current PTSD had lower ED values of HR and DBP.
The Peritraumatic Distress Inventory: a proposed measure of PTSD criterion A2.
The Peritraumatic Distress Inventory was found to be internally consistent, with good test-retest reliability and good convergent and divergent validity, and correlated with two measures of posttraumatic stress symptoms.
The eight‐item treatment‐outcome post‐traumatic stress disorder scale: a brief measure to assess treatment outcome in post‐traumatic stress disorder
The TOP-8 was developed from a larger post-traumatic stress disorder evaluation scale based on items which occurred frequently in the population and which responded substantially to treatment across time, and showed an improved ability to detect drug versus placebo differences in comparison with the original scale.
[Beta-blocking drugs and anxiety. A proven therapeutic value].
The therapeutic value of propranolol and other beta-adrenergic receptor blockers in anxiety disorders is reviewed. The potential side-effects of benzodiazepines, eg psychomotor impairment and
Toward an integrated neurobiology of panic disorder.
An integrated neurobiology of panic disorder will provide a broader conceptual framework with which to tackle the complex questions about the pathophysiology and treatment of this condition.