Immediate quantitation of antiarrhythmic drug effect by monophasic action potential recording in coronary artery disease.

@article{Platia1988ImmediateQO,
  title={Immediate quantitation of antiarrhythmic drug effect by monophasic action potential recording in coronary artery disease.},
  author={Edward V. Platia and Myron L. Weisfeldt and Michael R. Franz},
  journal={The American journal of cardiology},
  year={1988},
  volume={61 15},
  pages={
          1284-7
        }
}
Acute effects of intravenous magnesium on ventricular refractoriness and monophasic action potential duration in humans.
TLDR
Magnesium acutely shortens ventricular monophasic action potential duration and refractoriness and might bring salutary effects in arrhythmias evoked by prolonged repolarization.
Monophasic Action Potentials:
TLDR
This review aims to provide information on practical application of Monophaisc action potential recording in the clinical setting and the technical aspects of the MAP technique are described in detail.
Method and theory of monophasic action potential recording.
  • M. Franz
  • Biology, Medicine
    Progress in cardiovascular diseases
  • 1991
Procainamide and lidocaine produce dissimilar changes in ventricular repolarization and arrhythmogenicity in guinea‐pig
  • O. Osadchii
  • Biology, Medicine
    Fundamental & clinical pharmacology
  • 2014
TLDR
It is suggested that abnormal changes in repolarization may contribute to pro‐arrhythmic effects of procainamide.
Bridging the Gap Between Basic and Clinical Electrophysiology:
  • M. Franz
  • Medicine, Biology
    Journal of cardiovascular electrophysiology
  • 1994
TLDR
Monophasic action potential recordings are uniquely suited to detect early and delayed afterdepolarizations in the human heart, thereby helping to unravel the arrhythmia mechanisms in the long QT syndrome.
An Overview of QT Interval Assessment in Safety Pharmacology
TLDR
Experimental issues that should be considered when testing agents for their potential to cause arrhythmias, as well as general strategies for understanding the problems associated with this cardiovascular risk are discussed.
An Overview of QT Interval Assessment in Safety Pharmacology
TLDR
A strategy aimed at understanding the problems associated with this cardiovascular risk is discussed, which appears to possess reasonable predictive value but may depend largely on the experimental conditions employed.
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TLDR
These experiments suggest that therapeutic PA levels rapidly decrease PF automaticity, and within the same time span and range of plasma levels there are alterations in AP duration and refractoriness.
Long-term recording of monophasic action potentials from human endocardium.
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Monophasic action potential mapping in human subjects with normal electrocardiograms: direct evidence for the genesis of the T wave.
T wave concordance in the normal human electrocardiogram (ECG) generally is explained by assuming opposite directions of ventricular depolarization and repolarization; however, direct experimental
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In vitro validation of a new cardiac catheter technique for recording monophasic action potentials.
TLDR
Data confirm that monophasic action potential recordings recorded with this clinically safe contact electrode technique can be used to measure accurately the repolarization time course of transmembrane action potentials.
Monophasic Action Potentials in Man
TLDR
The study suggests that the monophasic action potential may be helpful in estimating the refractory period at the site of recording and in explaining the pathogenesis of abnormal repolarization in the electrocardiogram.
Localization of regional myocardial ischemia by recording of monophasic action potentials.
TLDR
Monophasic action potentials recorded from the myocardial surface by means of a new contact-electrode technique uniquely define ischemic and nonischemic sites and more precisely localize the border of an isChemic region.
Cesium chloride-induced long QT syndrome: demonstration of afterdepolarizations and triggered activity in vivo.
TLDR
A new catheter technique has been validated and has been used to directly identify afterdepolarizations and triggered activity in vivo and was closely related to arrhythmias.
Electrophysiological Effects of the Optical Isomers of Disopyramide and Quinidine in the Dog
TLDR
The results indicate that the stereochemical configurations of disopyramide and quinidine determine their effects on repolarization of cardiac Purkinje fibers.
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