Immediate hypothermia is not neuroprotective after severe hypoxia-ischemia and is deleterious when delayed by 12 hours in neonatal rats.

@article{Sabir2012ImmediateHI,
  title={Immediate hypothermia is not neuroprotective after severe hypoxia-ischemia and is deleterious when delayed by 12 hours in neonatal rats.},
  author={Hemmen Sabir and Emma Scull-Brown and Xun Liu and Marianne Thoresen},
  journal={Stroke},
  year={2012},
  volume={43 12},
  pages={3364-70}
}
BACKGROUND AND PURPOSE Hypothermia (HT) for neonatal hypoxic-ischemic encephalopathy is advised to start within the first 6 hours after birth. There is some clinical evidence that HT is more effective against moderate than against severe hypoxic-ischemic encephalopathy, but it is unknown whether delayed HT beyond 6 hours is effective or even injurious. METHODS One-hundred seven 7-day-old rat pups underwent unilateral hypoxia-ischemia of moderate severity. Pups were randomized to receive 5… CONTINUE READING
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