Immediate hemodynamic effects of a dopamine-receptor agonist (fenoldopam) in patients with essential hypertension.

Abstract

Systemic, splanchnic, and renal hemodynamics, intravascular volume, and reflexive and endocrine changes were measured before and after a single dose of fenoldopam, a novel antihypertensive agent that acts through stimulation of specific dopamine receptors. A 13% reduction in mean arterial pressure was mediated by a fall in total peripheral resistance association with an increase in cardiac index, heart rate, stroke volume, left ventricular ejection rate, and circumferential fiber shortening. Renal blood flow increased, thereby reducing the renal vascular resistance by more than 40%. In contrast, splanchnic hemodynamics failed to change. Likewise, there were no changes in intravascular volume, plasma renin activity, or norepinephrine, serum aldosterone, or prolactin levels.

5 Figures and Tables

Statistics

0204060'89'92'95'98'01'04'07'10'13'16
Citations per Year

144 Citations

Semantic Scholar estimates that this publication has 144 citations based on the available data.

See our FAQ for additional information.

Cite this paper

@article{Ventura1984ImmediateHE, title={Immediate hemodynamic effects of a dopamine-receptor agonist (fenoldopam) in patients with essential hypertension.}, author={Hector O. Ventura and F. H. Messerli and Edward David Frohlich and Isaac Kobrin and Wille Oigman and Frank G Dunn and Robert M . Carey}, journal={Circulation}, year={1984}, volume={69 6}, pages={1142-5} }