Immediate ex-vivo diagnosis of pituitary adenomas using confocal reflectance microscopy: a proof-of-principle study.

@article{Mooney2018ImmediateED,
  title={Immediate ex-vivo diagnosis of pituitary adenomas using confocal reflectance microscopy: a proof-of-principle study.},
  author={Michael A. Mooney and Joseph Georges and Mohammedhassan Izady Yazdanabadi and Katherine Y Goehring and William L. White and Andrew S. Little and Mark C. Preul and Stephen W. Coons and Peter Nakaji and Jennifer Eschbacher},
  journal={Journal of neurosurgery},
  year={2018},
  volume={128 4},
  pages={1072-1075}
}
OBJECTIVE The objective of this study was to evaluate the feasibility of using confocal reflectance microscopy (CRM) ex vivo to differentiate adenoma from normal pituitary gland in surgical biopsy specimens. CRM allows for rapid, label-free evaluation of biopsy specimens with cellular resolution while avoiding some limitations of frozen section analysis. METHODS Biopsy specimens from 11 patients with suspected pituitary adenomas were transported directly to the pathology department. Samples… CONTINUE READING
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