Immediate effects of spinal manipulation on nitric oxide, substance P and pain perception.

@article{MolinaOrtega2014ImmediateEO,
  title={Immediate effects of spinal manipulation on nitric oxide, substance P and pain perception.},
  author={Francisco Javier Molina-Ortega and Rafael Lomas-Vega and Fidel Hita-Contreras and Gustavo Plaza Manzano and Alexander Achalandabaso and Antonio J Ramos-Morcillo and Antonio Mart{\'i}nez-Amat},
  journal={Manual therapy},
  year={2014},
  volume={19 5},
  pages={411-7}
}
Previous studies have analyzed the effects of spinal manipulation on pain sensitivity by using several sensory modalities, but to our knowledge, no studies have focused on serum biomarkers involved in the nociceptive pathway after spinal manipulation. Our objectives were to determine the immediate effect of cervical and dorsal manipulation over the production of nitric oxide and substance P, and establishing their relationship with changes in pressure pain thresholds in asymptomatic subjects… CONTINUE READING
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